Cells and tissue from BioPredic
The French company BioPredic International have a long history providing primary cells and human tissue to the research and clinical markets. BioPredic exclusively are licensed to produce the INSERM HepaRG hepatocyte cell line, widely accepted as a valid alternative to fresh hepatocytes for drug registration toxicology studies. In addition to primary cells Biopredic are one of the largest suppliers of human skin and other human tissues for pharmaceutical and clinical drug research and for cosmetic testing.
The French company BioPredic International have a long history providing primary cells and human tissue to the research and clinical markets. BioPredic exclusively are licensed to produce the INSERM HepaRG hepatocyte cell line, widely accepted as a valid alternative to fresh hepatocytes for drug registration toxicology studies. In addition to primary cells Biopredic are one of the largest suppliers of human skin and other human tissues for pharmaceutical and clinical drug research and for cosmetic testing.
HepaRG cells have the unique properties of maintaining significant levels of hepatocyte functions, of being inducible and supporting the complete replicative cycle of HBV. Cells are coculture of hepatocyte like cells and biliary like epithelial cells and are available in monolayers, ready to use.
Download literature:
Functional Expression of Cytochrome P450 Enzymes in Human Hepatoma HepaRG Cell Line - a poster by Miia Turpeinen et al.
CHARACTERISATION OF CYTOCHROME P450 INDUCTION IN HEPA RG CELLS - poster by Kajsa P. Persson and Tommy B. Andersson.
Human hepatoma HepaRG cells: a unique model system for xenobiotic metabolism and toxicity studies - a poster by A. Corlu et al.
HepaRG Human Heptic Cell Line Specifications
Download literature:
Functional Expression of Cytochrome P450 Enzymes in Human Hepatoma HepaRG Cell Line - a poster by Miia Turpeinen et al.
CHARACTERISATION OF CYTOCHROME P450 INDUCTION IN HEPA RG CELLS - poster by Kajsa P. Persson and Tommy B. Andersson.
Human hepatoma HepaRG cells: a unique model system for xenobiotic metabolism and toxicity studies - a poster by A. Corlu et al.
HepaRG Human Heptic Cell Line Specifications
HepaRG hepatocytes
| • | A bipotent progenitor cell line |
| • | Stable & subnormal caryotype |
| • | Human adult liver phenotype |
| • | CYP, transporter & nuclear receptor expression comparable to that in primary hepatocytes |
Liver
| • | Hepatocytes - fresh or cryopreserved; human and animal |
| • | Precision cut liver slices - fresh or cryopreserved; human and animal |
| • | Frozen human liver |
| • | Microsomes; human and animal - single or pooled donors. Prepared from control or CYP induced animals |
| • | Vesicular membranes; canalicular membranes, for MRP2, BCRP & BSEP |
| • | S9, cytosols and mitochondria; human, rat, dog and monkey |
Human & Animal Tissues
| • | Slices: liver, kidney, lung - fresh or frozen |
| • | Nail - finger or toe |
| • | Cornea (Porcine isolated cornea) |
| • | Brain, liver, lung, skin, umbilical cord, placenta, whole blood, intestine, bone marrow, skeletal muscle, nasal polyps, and many others. For custom preps - please enquire |
Fluids for Bioanalysis
| • | Bile |
| • | Gastric & intestinal |
| • | Urine |
| • | Saliva |
| • | Abdominal and mammary |
| • | Full thickness dermatomed stratum corneum |
| • | Available as frozen sheets |
| • | Human skin cells: |
Human & Animal Skin
| O | Keratinocytes - pooled or single donar |
| O | Fibroblasts |
| O | Merkel cells |
| O | Human dermal microvascular endothelial cells |
Blood & Blood Fractions
| • | Whole blood,plasma & serum |
| • | Human, rodent, dog or monkey |
| • | Single donor or pooled |
| • | Adult or neonatal |
| • | LDL,HDL,VLDL fractions |
Human blood cells
| • | PBMC peripheral blood mononuclear cells |
| • | PBL peripheral blood lymphocytes |
| • | Monocytes |
| • | Monocyte derived dendritic cells |
| • | CBMC cord blood mononuclear cells |
| • | CBL cord blood lymphocytes |
| • | CD34+ from cord blood |
Genotoxicity
| • | S9 |
| • | HepaRG |
| • | Hepatocytes |
| • | Lymphocytes |
| • | Keratinocytes |
| • | Liverbeads - co incubation with target cells to add the metabolic competence |
Primary cells
| • | Liver - Hepatocytes and non parenchymal cells |
| • | Human bone marrow - MSC mesenchymal stem cells and BMMC bone marrow mononuclear cells |
| • | Brain (human and animal) - capillary brain endothelial cells, and Astrocytes & glial cells |
| • | Human adipose cells - Pre-adipocytes and abdominal or visceral origin |
| • | Muscle cells - human adult skeletal muscle cells |
| • | Kidney - human proximal tubular cells and rat proximal tubular cells |
| • | Endothelium (human and animal) - capillary brain endothelial cells, human umbilical vein endothelial cells (HUVEC) and human dermal microvascular endothelial cells |
| • | All other cells - please enquire |
Metabolism
| • | Cells - HepaRG, Hepatocytes, Keratinocytes |
| • | Organ Toxicology - Precision cut liver slices & hepatocytes, skin and keratinocytes, kidney slices and primary tubular cells, Blood (whole and cells, adult and cord) |
| • | Fractions - Microsomes, S9, Cytocols |
Kits & Recombined products
| • | Liver beads |
| • | Transporter membranes & Vesicles |
| • | HepaRG |
| • | CYP primers |
| • | AngioKit 24 and 96 well |
| • | BBB kit |
| • | Microsomes: |
Subcellular fractions
| • | S9 & cytosols: Liver,intestine, kidney, lung,skin |
| O | Liver - human, rat, mouse, dog, cynomolgus |
| O | Kidney - human |
| O | Lung - human and rat |
| O | Intestine - human, rat, mouse, dog |
| O | Human skin with validated expiry date |
Contact us for quantities & delivery schedules
